Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates

Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates

A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction

A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction

Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus

Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus

Diabetes, cancer, and metformin: connections of metabolism and cell proliferation

Diabetes, cancer, and metformin: connections of metabolism and cell proliferation

Nonalcoholic fatty pancreas disease

Nonalcoholic fatty pancreas disease

Does ADMA Cause Endothelial Dysfunction?

Does ADMA Cause Endothelial Dysfunction?

Bioavailability of Pure Isoflavones in Healthy Humans and Analysis of Commercial Soy Isoflavone Supplements

Bioavailability of Pure Isoflavones in Healthy Humans and Analysis of Commercial Soy Isoflavone Supplements

Differential Metabolic Effects of Saturated Versus Polyunsaturated Fats in Ketogenic Diets

Differential Metabolic Effects of Saturated Versus Polyunsaturated Fats in Ketogenic Diets

The O6/O3 Ratio & CVD - Concludes ratio of little value

The O6/O3 Ratio & CVD - Concludes ratio of little value

Is Weight Loss a Cure for Type 2 Diabetes? (2002)

Is Weight Loss a Cure for Type 2 Diabetes?

25 Years Progress in Type 2 Diabetes

[PDF] 

25 Years Progress in Type 2 Diabetes

C-Peptide as a Therapeutic Tool in Diabetic Nephropathy

C-Peptide as a Therapeutic Tool in Diabetic Nephropathy

Soy Isoflavones: Are They Useful in Menopause?

Soy Isoflavones: Are They Useful in Menopause?

Osteoporosis: An Under-appreciated Complication of Diabetes

Osteoporosis: An Under-appreciated Complication of Diabetes

Studies of insulin resistance in patients with clinical and subclinical hypothyroidism

Studies of insulin resistance in patients with clinical and subclinical hypothyroidism

Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes

Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes

Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A

Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A

Insulin, ketone bodies, and mitochondrial energy transduction.

Insulin, ketone bodies, and mitochondrial energy transduction.

Redox Potentials for Free Radicals & AntiOxidants

The Pecking Order of Free Radicals and AntiOxidants

Emerging Role of Adipose Tissue Hypoxia in Obesity and Insulin Resistance

Emerging Role of Adipose Tissue Hypoxia in Obesity and Insulin Resistance

Regulation of metabolic genes in human skeletal muscle by short-term exercise and diet manipulation

Regulation of metabolic genes in human skeletal muscle by short-term exercise and diet manipulation

Effects of Genetic Variation in the Human Retinol Binding Protein-4 Gene (RBP4) on Insulin Resistance and Fat Depot–Specific mRNA Expression

Effects of Genetic Variation in the Human Retinol Binding Protein-4 Gene (RBP4) on Insulin Resistance and Fat Depot–Specific mRNA Expression

Retinol-Binding Protein 4 Is Associated with Insulin Resistance and Body Fat Distribution in Nonobese Subjects without Type 2 Diabetes

Retinol-Binding Protein 4 Is Associated with Insulin Resistance and Body Fat Distribution in Nonobese Subjects without Type 2 Diabetes

RBP4, an unexpected adipokine

RBP4, an unexpected adipokine

Retinol Binding Protein-4 Levels and Clinical Features of Type 2 Diabetes Patients

Retinol Binding Protein-4 Levels and Clinical Features of Type 2 Diabetes Patients

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Effect of Weight Loss on LDL and HDL Kinetics in the Metabolic Syndrome

Effect of Weight Loss on LDL and HDL Kinetics in the Metabolic Syndrome 
Associations with changes in plasma retinol-binding protein-4 and adiponectin levels

Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis

Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis

The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance

The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance

Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance

Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance

A Ceramide-Centric View of Insulin Resistance

A Ceramide-Centric View of Insulin Resistance

Q&A: 'Toxic' effects of sugar: should we be afraid of fructose?

Q&A: 'Toxic' effects of sugar: should we be afraid of fructose?

Lactate metabolism: a new paradigm for the third millennium

Lactate metabolism: a new paradigm for the third millennium

Amino Acid SYNTHESIS Metabolic Pathways ~ Graphic

From Google Images, original blog post unavailable, therefore source unknown.

Hepatic and Whole Body Lipogenesis in Humans

Hepatic and Whole Body Lipogenesis in Humans

Differential regulation of fatty acid trapping in mouse adipose tissue and muscle by ASP

Differential regulation of fatty acid trapping in mouse adipose tissue and muscle by ASP

Mechanisms Involved in the Regulation of Free Fatty Acid Release from Isolated Human Fat Cells by Acylation-stimulating Protein and Insulin

Mechanisms Involved in the Regulation of Free Fatty Acid Release from Isolated Human Fat Cells by Acylation-stimulating Protein and Insulin

Mechanisms of nutritional and hormonal regulation of lipogenesis

Mechanisms of nutritional and hormonal regulation of lipogenesis

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

High Circulating Leptin Receptors with Normal Leptin Sensitivity in Liver-specific Insulin Receptor Knock-out (LIRKO) Mice

High Circulating Leptin Receptors with Normal Leptin Sensitivity in Liver-specific Insulin Receptor Knock-out (LIRKO) Mice

Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis

Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis

Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism

Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism

Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: a potential mechanism for hyperinsulinaemia-associated leptin resistance.

Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: a potential mechanism for hyperinsulinaemia-associated leptin resistance.

Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons

Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons

Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions

Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions

Fatty acid composition in serum lipids and adipose tissue in severe obesity before and after six weeks of weight loss

Fatty acid composition in serum lipids and adipose tissue in severe obesity before and after six weeks of weight loss  {abstract only}

Effect of Macronutrient Composition on Postprandial Peptide YY Levels

Effect of Macronutrient Composition on Postprandial Peptide YY Levels

Effect of Caloric Restriction during Pregnancy on Maternal and Fetal Body Composition in the Obese Sprague-Dawley Rat

Effect of Caloric Restriction during Pregnancy on Maternal and Fetal Body Composition in the Obese Sprague-Dawley Rat

DAF-2/Insulin-Like Signaling in C. elegans Modifies Effects of Dietary Restriction and Nutrient Stress on Aging, Stress and Growth

DAF-2/Insulin-Like Signaling in C. elegans Modifies Effects of Dietary Restriction and Nutrient Stress on Aging, Stress and Growth

Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum

Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum

Cellular and Molecular Characterization of the Adipose Phenotype of the Aromatase-Deficient Mouse

Cellular and Molecular Characterization of the Adipose Phenotype of the Aromatase-Deficient Mouse

Estrogen deficiency in the aromatase knockout (ArKO) mouse leads to the development of obesity by as early as 3 months of age, which is characterized by a marked increase in the weights of gonadal and infrarenal fat pads. Humans with natural mutations of the aromatase gene also develop a metabolic syndrome. In the present study cellular and molecular parameters were investigated in gonadal adipose tissue from 10-wk-old wild-type (WT) and ArKO female mice treated with 17β-estradiol or placebo to identify the basis for the increase in intraabdominal obesity. Stereological examination revealed that adipocytes isolated from ArKO mice were significantly larger and more abundant than adipocytes isolated from WT mice. Upon treatment with estrogen, the volume of these adipocytes was greatly reduced, whereas the reduction in the number of adipocytes was much less pronounced. Transcriptional analysis using real-time PCR revealed concomitant changes with adipocyte volume in the levels of transcripts encoding leptin and lipoprotein lipase, whereas peroxisome proliferator-activated receptor γ levels followed a pattern closer to that of adipocyte number. Little change was observed in levels of transcripts for factors involved in de novo fatty acid synthesis, β-oxidation, and lipolysis, suggesting that changes in the uptake of lipids from the circulation are the main mechanisms by which estrogen regulates lipid metabolism in these mice.

Elevated Free Fatty Acids Impair Glucose Metabolism in Women

Elevated Free Fatty Acids Impair Glucose Metabolism in Women

Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity

Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity

The aromatase-knockout (ArKO) mouse provides a useful model to examine the role that estrogens play in development and homeostasis in mammals. Lacking a functional Cyp19 gene, which encodes aromatase, the ArKO mouse cannot synthesize endogenous estrogens. We examined the adipose depots of male and female ArKO mice, observing that these animals progressively accumulate significantly more intraabdominal adipose tissue than their wild-type (WT) littermates, reflected in increased adipocyte volume at gonadal and infrarenal sites. This increased adiposity was not due to hyperphagia or reduced resting energy expenditure, but was associated with reduced spontaneous physical activity levels, reduced glucose oxidation, and a decrease in lean body mass. Elevated circulating levels of leptin and cholesterol were present in 1-year-old ArKO mice compared with WT controls, as were elevated insulin levels, although blood glucose levels were unchanged. Associated with these changes, a striking accumulation of lipid droplets was observed in the livers of ArKO animals. Our findings demonstrate an important role for estrogen in the maintenance of lipid homeostasis in both males and females.  

Intrinsic Heterogeneity in Adipose Tissue of Fat-specific Insulin Receptor Knock-out Mice Is Associated with Differences in Patterns of Gene Expression

Intrinsic Heterogeneity in Adipose Tissue of Fat-specific Insulin Receptor Knock-out Mice Is Associated with Differences in Patterns of Gene Expression

Increased Plasma Acylation-Stimulating Protein Correlates with Hyperlipidemia at Late Gestation

Increased Plasma Acylation-Stimulating Protein Correlates with Hyperlipidemia at Late Gestation

Reduced Adiposity in ob/ob Mice following Total Body Irradiation and Bone Marrow Transplantation

Reduced Adiposity in ob/ob Mice following Total Body Irradiation and Bone Marrow Transplantation

Postprandial hyperinsulinemia in patients with mild essential hypertension

Postprandial hyperinsulinemia in patients with mild essential hypertension

Sucrose substitution in prevention and reversal of the fall in metabolic rate accompanying hypocaloric diets

Sucrose substitution in prevention and reversal of the fall in metabolic rate accompanying hypocaloric diets
{Abstract only}

Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

Reduction of Hepatic CEACAM1 Levels: An Early Mechanism Insulin Resistance Induced by High-Fat Diet

Reduction of Hepatic CEACAM1 Levels: An Early Mechanism Insulin Resistance Induced by High-Fat Diet
PhD Thesis --

Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress

Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress